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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCN8A All Species: 22.73
Human Site: S594 Identified Species: 50
UniProt: Q9UQD0 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQD0 NP_055006.1 1980 225280 S594 E H S T V E E S E G R R D S L
Chimpanzee Pan troglodytes XP_001141985 1976 224859 S594 E H S T V E E S E G R R D S L
Rhesus Macaque Macaca mulatta XP_001090295 1980 225320 S594 E H S T V E E S E G R R D S L
Dog Lupus familis XP_850134 1980 225167 S594 E H S T V E E S E G R R D S L
Cat Felis silvestris
Mouse Mus musculus Q9WTU3 1978 225123 S594 E H S T V E E S E G R R D S L
Rat Rattus norvegicus O88420 1978 225141 S594 E H S T V E E S E G R R D S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512721 2008 228348 N606 E H S T F E D N D S R R D S L
Chicken Gallus gallus XP_424477 1978 225428 G592 S T V E E S E G R R D S L F I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q20JQ7 1784 201644 C534 Q E D I E R P C P P G W Y K F
Tiger Blowfish Takifugu rubipres Q2XVR7 1892 213080 A551 R S A S V A T A A A S V A T A
Fruit Fly Dros. melanogaster P35500 2131 239344 L657 S Y T S H G D L L G G M A V M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.8 99.9 99.3 N.A. 98.4 98.5 N.A. 76.9 94.2 N.A. 61.9 61.6 44.3 N.A. N.A. N.A.
Protein Similarity: 100 97.1 99.9 99.6 N.A. 99.4 99.4 N.A. 86.8 97 N.A. 73.8 73.4 61.3 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 66.6 6.6 N.A. 0 6.6 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 86.6 13.3 N.A. 6.6 33.3 40 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 10 0 10 10 10 0 0 19 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 0 0 19 0 10 0 10 0 64 0 0 % D
% Glu: 64 10 0 10 19 64 64 0 55 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 10 % F
% Gly: 0 0 0 0 0 10 0 10 0 64 19 0 0 0 0 % G
% His: 0 64 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 10 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % K
% Leu: 0 0 0 0 0 0 0 10 10 0 0 0 10 0 64 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 10 0 10 10 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 0 0 0 10 0 0 10 10 64 64 0 0 0 % R
% Ser: 19 10 64 19 0 10 0 55 0 10 10 10 0 64 0 % S
% Thr: 0 10 10 64 0 0 10 0 0 0 0 0 0 10 0 % T
% Val: 0 0 10 0 64 0 0 0 0 0 0 10 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _